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ANC Workshop Talk: Douglas Armstrong and Seymour Knowles Barley, Chair: Lysimachos Zografos

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What
  • ANC Workshop Talk
When Feb 21, 2012
from 11:00 AM to 12:00 PM
Where IF 4.31/4.33
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Douglas Armstrong

Anxiety in the UK…

I suppose it should really be Anxiety in Zebafish but never let the science stand in the way of your talk title. I am going to talk about some recent work between Actual Analytics and Liz Patton's group at the MRC Human Genetics unit in Edinburgh. I will focus on our development and use of tracking to measure group behaviour in adult fish. The results were used to measure anxiety related behavioural traits in wild-type, mutant and the responses of both to drug treatments.

 

Seymour Knowles-Barley

My PhD in 30 Minutes or Less:
Proteins, Anatomy and Networks of the Fruit Fly Brain

Our understanding of the complexity of the brain is limited by the data we can collect and analyze. Because of experimental limitations and a desire for greater detail, most investigations focus on just one aspect of the brain. For example, brain function can be studied at many levels of abstraction including, but not limited to, gene expression, protein interactions, anatomical regions, neuronal connectivity, synaptic plasticity, and the electrical activity of neurons. By focusing on each of these levels, neuroscience has built up a detailed picture of how the brain works, but each level is understood mostly in isolation from the others. It is likely that interaction between all these levels is just as important. Therefore, a key hypothesis is that functional units spanning multiple levels of biological organization exist in the brain.

This project attempted to combine neuronal circuitry analysis with functional proteomics and anatomical regions of the brain to explore this hypothesis, and took an evolutionary view of the results obtained. During the process we had to solve a number of technical challenges, as the tools to undertake this type of research did not exist. Two informatics challenges for this research were to develop ways to analyze neurobiological data, such as brain protein expression patterns or neural circuit reconstruction data, to extract useful information, and how to share and present this data in a way that is fast and easy for anyone to access.

http://fruitfly.inf.ed.ac.uk/~cmor/thesis/PhDThesis.pdf