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ANC Workshop Talk: Lukas Solanka and Ian Simpson, Chair: Michael Hull

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What
  • ANC Workshop Talk
When May 29, 2012
from 11:00 AM to 12:00 PM
Where IF 4.31/4.33
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Lukas Solanka

Role of inhibitory feedback in an attractor network model of layer II of the medial entorhinal cortex

Grid cells in the medial entorhinal cortex (MEC) encode location through firing fields that form grid-like maps of the environment. At the same time network activity in the MEC is dominated by oscillations in the theta (4-12 Hz) and gamma (30-100 Hz) bands. The relationship between oscillatory activity and grid firing is not known. Our recent experimental data established that feedback inhibition between excitatory stellate cells and inhibitory fast spiking interneurons dominates the synaptic connectivity in layer II of the MEC. We therefore constructed a spiking attractor network model in which stellate cells connect exclusively to interneurons, while interneurons contact only excitatory cells. The presence of feedback inhibition, along with external theta modulated drive, can explain both grid-like receptive fields and theta-nested gamma oscillations.

 

Ian Simpson

Identifying novel candidate genes for Ciliopathic disease using transcriptomic, proteomic and meta-genomic data
 
Over the last decade a number of apparently unrelated diseases have been found to have underlying deficits in cilial function. To date over 20 such ciliopathies have been described with mutations in more than 80 genes whose proteins localise to the cilium. Using novel expression data  in concert with publicly available proteomic, protein-protein interaction, disease association and gene functional annotation data we have used integrative modelling approaches to build both protein-protein interaction networks (PINs) and human disease networks (HDNs) that reveal both novel disease associated proteins and infer new disease candidate genes to facilitate a more complete understanding of the complex aetiology of ciliopathic diseases.