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ANC Workshop Talk: David Acunzo and Ronald Begg, Chair: Nestor Milyaev

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What
  • ANC Workshop Talk
When Mar 13, 2012
from 11:00 AM to 12:10 PM
Where IF G.03
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David Acunzo

Very early modulations of visual processing by attention and emotion: genuine effect or processing artifact?

Abstract: Recently, several EEG and MEG studies have reported top-down modulations of the visually evoked waveform at a very early latency (i.e.< 100 ms). These very early modulations may reflect the fact that endogenous attentional effect and some stages of high-level visual processing (in particular facial processing) happen earlier than was generally thought. With some of my own data, I will show that an important portion of the effects reported in the literature may simply be artifacts due to digital filtering.

 

Ronald Begg

Inference and Comparison of Transcription Factor Activity from Gene Expression Data

The degree which genes are expressed are affected by various proteins called transcription factors.  The expression levels of the genes which produce these transcription factors is often quite low and noisy, while the transcription factor
proteins may also exist in active or inactive states.  Thus, the level of expression of transcription factor genes is not necessarily a reliable indicator of transcription factor activity.

Previous work by Sanguinetti et al. has provided a frame-work for inferring transcription factor activities from high-throughput gene-expression data.

Currently we have gene expression data obtained by growing E. coli in different conditions which include, among others, the presence of a Carbon Monoxide-Releasing Molecule or the deactivated version of the same molecule.   We are interested in comparing transcription factor profile activities between different conditions.