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ANC Workshop Talk: Helen Ramsden and Grigorios Sotiropoulos, Chair: Ronald Begg

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What
  • ANC Workshop Talk
When Jul 10, 2012
from 11:00 AM to 12:00 PM
Where IF 4.31/4.33
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Helen Ramsden
Mapping genes to function in mouse medial entorhinal cortex
 
Neurons in the mouse medial entorhinal cortex (MEC) encode an animal’s position in space, and are therefore of interest for understanding the cellular mechanisms of spatial encoding. There is a gradient in the resolution of this spatial code that maps onto differences in the timing with which cells integrate their inputs from other cells. We hypothesise that the network is functionally organised such that cells along the dorso-ventral axis exhibit systematically different internal characteristics.

To probe such differences, we have investigated the genetic profile of these cells using the Allen Brain Atlas database of in situ hybridisation images for over 20000 genes in the mouse. We find that: (1) gene expression clearly follows anatomical boundaries, as well as the dorso-ventral gradient in spatial resolution; (2) functionally interesting genes such as ion channels and synapse-associated genes, as well as disease-associated genes, show high levels of differential expression in MEC, and are specifically enriched along the dorsal-ventral gradient. This not only provides candidate genes for experimental study, but will also enable us to identify potential transcription factors that regulate groups of genes to maintain specific functions and variation within MEC.