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ANC Workshop: Ronald Begg, Chair: Sergio Gonzalez

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Determining the effects of Carbon Monoxide Releasing Molecules on the transcriptional regulation of E. Coli

What
  • ANC Workshop Talk
When Jan 22, 2013
from 11:00 AM to 11:30 AM
Where IF 4.31/4.33
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My project involves working with gene-expression time-series data from experiments involving E. Coli exposed to Carbon-Monoxide releasing molecules (CORMs), inactive versions of the molecules (iCORMs) and, recently, CO-gas.

Two questions I have been looking at are inferring from gene expression data such things as transcription factor activity or network structure.  Of specific interest is the comparisson of the results between two data-sets; for example, given the gene-experssion time-series under exposure to CORMs or iCORMs, to determine whether the activity of a given transcription factor is affected differently, or to determine whether the edges within a certain component of the gene regulatory network are different under the different conditions.