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ANC Seminar: Ke Yuan (Glasgow), Host: Guido Sanguinetti

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Uncovering intratumor heterogeneity with Dirichlet processes

What
  • ANC/DTC Seminar
When Oct 11, 2016
from 11:00 AM to 12:00 PM
Where IF 4.31/4.33
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Carcinogenesis is an evolutionary process in which advantageous mutations accumulate over time and cells harbouring these mutations give rise to new clones. The nature of this progressing disease makes time course analysis very difficult and therefore the composition of these clones is generally unknown. I will discuss methods designed to identify intratumoral cancer clones. A common foundation of the methods is Dirichlet process, by which the number of clones and their evolutionary relationships can be inferred. In two case studies, I will demonstrate applications in reconstructing intratumoral phylogenies from DNA methylation profiles and somatic mutations identified by single-cell sequencing. Finally, I will showcase an ongoing project on clonality analysis for whole-genome sequencing data.

Short Bio
Ke Yuan is a Lecturer in Computing Science at the University of Glasgow. He received a PhD from the University of Southampton in 2013 advised by Mahesan Niranjan. Till 04/2016, He was a postdoctoral research fellow at Cancer Research UK Cambridge Institute at University of Cambridge working with Florian Markowetz. He joined the School of Computing Science at the University of Glasgow in 05/2016.