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ANC/DTC Seminar: Rob Williams, University of Tennessee (Host: Douglas Armstrong)

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From Basepair to Behavior: Using a Systems Genetics Approach to Probe Brain Structure and Function

What
  • ANC/DTC Seminar
When Feb 26, 2013
from 11:00 AM to 12:00 PM
Where IF 4.31/4.33
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Many neuroscientists are interested in understanding complex networks of molecules and cellular processes that modulate structural and behavioral variation in the brain. Over the past several years our team has produced unique tissue and transcriptome resources and companion on-line analytic and stereological tools as part of GeneNetwork (www.genenetwork.org <http://www.genenetwork.org/>) and the Mouse Brain Library (www.mbl.org <http://www.mbl.org/>). This set of neuroinformatics resources is now being used by neuroscientists and geneticists to systematically study the complex genetics of the mammalian brain in terms of development, architecture, function, and pathology. In this presentation I will review these online resources, and demonstrate how they can be used to elucidate functions of gene networks that modulate variation in both the hippocampus and striatum by exploiting multiscale data generated using a panel of 100 diverse strains of mice.