We propose to develop and adapt whole-brain tractography and computational network analysis methods to assess white matter integrity in healthy, elderly and diseased populations using diffusion magnetic resonance imaging (dMRI). Briefly, our analysis method involves:
1) segmentation of cortical regions;
2) construction of a structural network using dMRI and established tractography algorithms;
3) computational network analysis to assess the connections between cortical regions. Network properties may then be used to characterise the overall integrity of networks in the brain and may serve as useful biomarkers for assessing changes associated with normal ageing and disease states such as brain tumours.
Related Publications and Presentations
- Colin R. Buchanan, Krzysztof J Gorgolewski, Cyril Pernet, Amos Storkey, and Mark Bastin, “Quantifying the intra- and inter-subject variability of whole-brain structural networks from diffusion MRI”, Proceedings of the ISMRM, 20th Annual Meeting, 2012, 20, 1929.
- Colin R. Buchanan, “Whole‐brain structural networks from diffusion MRI”, 2nd UK Neuroinformatics Node Congress, 2012.
- Colin R. Buchanan, Cyril Pernet, Krzysztof J Gorgolewski, Amos Storkey, and Mark Bastin, “The test-retest reliability of structural brain networks obtained from diffusion MRI”, 19th Annual Meeting of the Organization for Human Brain Mapping, 2013.
- Colin R. Buchanan, Lewis Pettit, Mark Bastin, Amos Storkey, and Sharon Abrahams, “Structural Brain Networks in Amyotrophic Lateral Sclerosis”, 19th Annual Meeting of the Organization for Human Brain Mapping, 2013.