I am interested in how DNA methylation gives rise to transcriptional regulation. To address this question, I will be developing machine learning methods to analyse higher order features of next generation sequencing data.
As the project develops, I aim to develop rigorous analytical tools to integrate data pertaining to other epigenetic mechanisms. These will be used to explore how distinct epigenetic mechanisms interact.
In particular, I will explore the interactions between methylation and MeCP2 binding. MeCP2 is an important protein for healthy neuronal function. Mutations in this gene are responsible for Rett Syndrome, which is debilitating in females and fatal in males