Translation regulation in synaptic plasticity. Evolutionary conservation and emergence of complex function (PhD)

Synapses evolved from early protosynaptic complexes in unicellular eukaryotes to sophisticated machineries with thousands of proteins, capable of finely-tuned plasticity.
This evolutionary leap which allowed for higher cognitive functions was paralleled by rapid development of regulation.
Using the wealth of high-throughput data the study will aim to quantify contribution of miRNA regulatory mechanism evolution to emergence and refinement of synaptic plasticity.
Also, other regulatory mechanisms will be investigated in the context of synaptic plasticity and neuropsychiatric diseases evolution.
The computational methods will focus on miRNA target prediction, network inference and molecular phylogenetics.
The findings will impact basic research as well as investigation of synapse-related diseases.

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