Neural variability and coding in the motor cortex (PhD)

This project has two goals: (i) to investigate the relationship between trial-to-trial variability in the motor cortex and the variability of the behavioural output, (ii) to study the functional role of the cortical layers in the motor cortex. The study combines computational and experimental methods. Computation: the idea is to explore the motor cortex by adopting spiking-networks. The focus will be (i) on the investigation of the balance between excitation and inhibition and (ii) on the propagation of signals across different layers. Experiments: whole cell in vivo recordings from awake behaving mice during the execution of natural and learned movements.

Related Themes

Related Publications and Presentations

  • Paolo Puggioni, Miha Pelko, Mark C W Van Rossum, and Ian Duguid, “Layer specific sub- and suprathreshold coding of voluntary movements in the motor cortex of awake mice”, Society for Neuroscience (SfN), 2012. View Details
  • Paolo Puggioni, Mark C W Van Rossum, and Ian Duguid, “Layer Specific Sub- And Suprathreshold Coding Of Voluntary Movements In The Motor Cortex Of Awake Mice”, FENS Abstracts, 2012.
  • Paolo Puggioni, Miha Pelko, Mark C W Van Rossum, and Ian Duguid, “Integrative properties of motor cortex pyramidal cells during quiet wakefulness and movement”, COSYNE, 2013.
  • Paolo Puggioni, Miha Pelko, Ian Duguid, and Mark C W Van Rossum, “Behavioral state differentially regulates input sensitivity and firing rates of motor cortex pyramidal neurons”, Computational Neuroscience (CNS), Paris 2013, 2013.

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