Developing advanced diffusion MR imaging (dMRI) methods (PhD)

The focus of my PhD work is the white matter that makes up the “wiring” of the brain. It is thought that even quite small defects in this wiring, perhaps arising due to disease or normal ageing, may adversely affect the brain’s ability to process information. I am applying ideas and techniques from computer science to the analysis of magnetic resonance imaging (MRI) data, with the aim of improving the information available from this clinical brain scanning technique. The hope is to provide computational tools for improving diagnosis and prognosis of pathologies involving white matter.

Related Themes

Related Publications and Presentations

  • Mark Bastin, Jonathan D. Clayden, J.M. Starr, and Joanna Wardlaw, “White matter integrity and cognition in childhood and old age: a diffusion tensor MRI study, Methods for Quantitative MRI of Human Brain”, ISMRM Workshop, 2005.
  • I. J. Deary, Mark Bastin, A. Pattie, Jonathan D. Clayden, L.J. Whalley, J.M. Starr, and Joanna Wardlaw, “White matter integrity and cognition in childhood and old age”, Neurology, 2007, 66(4), 505-512. View Details PDF
  • Mark Bastin, Jakub Przemyslaw Piatkowski, Amos Storkey, Laura J. Brown, Alasdair M.J. MacLullich, and Jonathan D. Clayden, “Tract shape modelling provides evidence of topological change in corpus callosum genu during normal ageing”, NeuroImage, 2008, 43(1), 20-28.
  • Jonathan D. Clayden, Dominic K.S. Marjoram, Mark Bastin, and Stephen Lawrie, “Towards an automated method for white matter integrity comparison between populations”, Proceedings of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB) 22nd Annual Meeting, Basel, Switzerland, 2005.
  • Jonathan D. Clayden, Mark Bastin, and Amos Storkey, “Neighbourhood tractography: a new approach to seed point placement for fibre tracking”, Proceedings of the British Chapter of the ISMRM, Guildford, UK, 2006.
  • Jonathan D. Clayden, “Improving the consistency of tract segmentation between subjects with neighbourhood tractography”, Cubric Centre at Cardiff University, 2006.
  • Jonathan D. Clayden, Mark Bastin, and Amos Storkey, “Improved segmentation reproducibility in group tractography using a quantitative tract similarity measure”, NeuroImage, 2007, 33(2), 482-492.
  • Jonathan D. Clayden, S. Zhang, S. Correia, and D.H. Laidlaw, “Fine-grained comparison of anisotropy differences between groups of white matter tracts”, ISMRM-ESMRMB Joint Annual Meeting, Berlin, 2007.
  • Mark Bastin, Jonathan D. Clayden, and Joanna Wardlaw, “DTI and MTI parameters correlate in periventricular white matter hyperintensities in old age”, ISMRM-ESMRMB Joint Annual Meeting, Berlin, 2007.
  • Mark Bastin, Jonathan D. Clayden, A. Pattie, I.F. Gerrish, Joanna Wardlaw, and I. J. Deary, “Diffusion tensor and magnetization transfer MRI measurements of periventricular white matter hyperintensities in old age”, Neurobiology of Aging, 2007.
  • Mark Bastin, Jonathan D. Clayden, and Joanna Wardlaw, “Cognitive ageing and white matter integrity: a diffusion tensor and magnetisation transfer MRI study”, Proceedings of the ISMRM, 13th Scientific Meeting & Exhibition, Miami, USA, 2005.
  • Jonathan D. Clayden, Mark Bastin, and Amos Storkey, “Automated assessment of tract similarity in group diffusion MRI data”, Proceedings of the ISMRM, 14th Scientific Meeting & Exhibition, Seattle, 2006.
  • Jonathan D. Clayden, Amos Storkey, and Mark Bastin, “A probabilistic model-based approach to consistent white matter tract segmentation”, ISMRM-ESMRMB Joint Annual Meeting, Berlin, 2007.
  • Jonathan D. Clayden, Amos Storkey, and Mark Bastin, “A probabilistic model-based approach to consistent white matter tract segmentation”, IEEE Transactions on Medical Imaging, 2007.

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