Matthew Down PhD

Matthew Down


Publications:
2015
  Validating a standardised test battery for synesthesia
Carmichael, DA, Down, MP, Shillcock, RC, Eagleman, DM & Simner, J 2015, 'Validating a standardised test battery for synesthesia: Does the Synesthesia Battery reliably detect synesthesia?' Consciousness and Cognition, vol 33, pp. 375-385. DOI: 10.1016/j.concog.2015.02.001

Synesthesia is a neurological condition that gives rise to unusual secondary sensations (e.g., reading letters might trigger the experience of colour). Testing the consistency of these sensations over long time intervals is the behavioural gold standard assessment for detecting synesthesia (e.g., Simner, Mulvenna et al., 2006). In 2007 however, Eagleman and colleagues presented an online 'Synesthesia Battery' of tests aimed at identifying synesthesia by assessing consistency but within a single test session. This battery has been widely used but has never been previously validated against conventional long-term retesting, and with a randomly recruited sample from the general population. We recruited 2847 participants to complete The Synesthesia Battery and found the prevalence of grapheme-colour synesthesia in the general population to be 1.2%. This prevalence was in line with previous conventional prevalence estimates based on conventional long-term testing (e.g., Simner, Mulvenna et al., 2006). This reproduction of similar prevalence rates suggests that the Synesthesia Battery is indeed a valid methodology for assessing synesthesia.


General Information
Organisations: School of Philosophy, Psychology and Language Sciences.
Authors: Carmichael, D A, Down, M P, Shillcock, R C, Eagleman, D M & Simner, J.
Keywords: (Synesthesia , Validation , Test , Assessment , Consistency , Prevalence , Grapheme-colour. )
Number of pages: 11
Pages: 375-385
Publication Date: May 2015
Publication Information
Category: Article
Journal: Consciousness and Cognition
Volume: 33
ISSN: 1053-8100
Original Language: English
DOIs: 10.1016/j.concog.2015.02.001
2013
  Steerable-filter based quantification of axonal populations at the developing optic chiasm reveal significant defects in Slit2(-/-) as well as Slit1(-/-)Slit2(-/-) embryos
Down, M, Willshaw, DA, Pratt, T & Price, D 2013, 'Steerable-filter based quantification of axonal populations at the developing optic chiasm reveal significant defects in Slit2(-/-) as well as Slit1(-/-)Slit2(-/-) embryos' BMC Neuroscience, vol 14, pp. 9. DOI: 10.1186/1471-2202-14-9
Previous studies have suggested that the axon guidance proteins Slit1 and Slit2 co-operate to establish the optic chiasm in its correct position at the ventral diencephalic midline. This is based on the observation that, although both Slit1 and Slit2 are expressed around the ventral midline, mice defective in either gene alone exhibit few or no axon guidance defects at the optic chiasm whereas embryos lacking both Slit1 and Slit2 develop a large additional chiasm anterior to the chiasm's normal position. Here we used steerable-filters to quantify key properties of the population of axons at the chiasm in wild-type, Slit1(-/-), Slit2(-/-) and Slit1(-/-)Slit2(-/-) embryos.
General Information
Organisations: Centre for Integrative Physiology.
Authors: Down, Matthew, Willshaw, David A, Pratt, Thomas & Price, David.
Keywords: (Animals, Axons, Body Patterning, Carbocyanines, Embryo, Mammalian, Filtration, Gene Expression Regulation, Developmental, Genotype, Intercellular Signaling Peptides and Proteins, Mice, Mice, Knockout, Nerve Tissue Proteins, Optic Chiasm, Visual Pathways. )
Pages: 9
Publication Date: 2013
Publication Information
Category: Article
Journal: BMC Neuroscience
Volume: 14
ISSN: 1471-2202
Original Language: English
DOIs: 10.1186/1471-2202-14-9
2012
  Following The Assembly Of Functional Circuitry: High Resolution Large-Scale Population Neuronal Dynamics In The Neonatal Mouse Retina In Health And Disease
Sernagor, E, Hennig, M, Gandolfo, M, Down, M, Jones, A, Eglen, S & Berdondini, L 2012, Following The Assembly Of Functional Circuitry: High Resolution Large-Scale Population Neuronal Dynamics In The Neonatal Mouse Retina In Health And Disease. in 8th Int. Meeting on Substrate-Integrated Microelectrodes. BIOPRO Baden-Württemberg GmbH.
General Information
Organisations: Institute for Adaptive and Neural Computation .
Authors: Sernagor, Evelyne, Hennig, Matthias, Gandolfo, Mauro, Down, Matthew, Jones, Alyssa, Eglen, Stephen & Berdondini, Luca.
Publication Date: 2012
Publication Information
Category: Conference contribution
Original Language: English
2011
  Analysis of simultaneous multielectrode recordings with 4,096 channels: changing dynamics of spontaneous activity in the developing retina
Hennig, M, Maccione, A, Gandolfo, M, Down, M, Eglen, S, Berdondini, L & Sernagor, E 2011, 'Analysis of simultaneous multielectrode recordings with 4,096 channels: changing dynamics of spontaneous activity in the developing retina' BMC Neuroscience, vol 12, no. Supplement 1, P296. DOI: 10.1186/1471-2202-12-S1-P296
General Information
Organisations: Institute for Adaptive and Neural Computation .
Authors: Hennig, Matthias, Maccione, Alessandro, Gandolfo, Mauro, Down, Matthew, Eglen, Stephen, Berdondini, Luca & Sernagor, Evelyne.
Number of pages: 2
Publication Date: 2011
Publication Information
Category: Meeting abstract
Journal: BMC Neuroscience
Volume: 12
Issue number: Supplement 1
ISSN: 1471-2202
Original Language: English
DOIs: 10.1186/1471-2202-12-S1-P296
  High resolution spatiotemporal analysis of mouse retinal waves during postnatal development
Sernagor, E, Hennig, M, Maccione, A, Gandolfo, M, Down, M, van Coppenhagen, J, Eglen, S & Berdondini, L 2011, High resolution spatiotemporal analysis of mouse retinal waves during postnatal development. in Proc. Society for Neuroscience Annual Meeting (SFN'11).
General Information
Organisations: Institute for Adaptive and Neural Computation .
Authors: Sernagor, Evelyne, Hennig, Matthias, Maccione, Alessandro, Gandolfo, Mauro, Down, Matthew, van Coppenhagen, James, Eglen, Stephen & Berdondini, Luca.
Publication Date: 2011
Publication Information
Category: Conference contribution
Original Language: English
2010
  Algorithms for automatic neuron tracing in noisy 3D image stacks
Knowles-Barley, S, Phillipson, G, Teriakidis, A, Sterratt, D, Larkworthy, T, O'Leary, T, Down, MP, Hennig, M, Withers, JPJ & Hull, M 2010, 'Algorithms for automatic neuron tracing in noisy 3D image stacks' Neuroscience Day 2010, Edinubrgh, United Kingdom, 29/03/10 - 29/03/10, .
General Information
Organisations: Institute for Adaptive and Neural Computation .
Authors: Knowles-Barley, Seymour, Phillipson, Graeme, Teriakidis, Adrianna, Sterratt, David, Larkworthy, Thomas, O'Leary, Timothy, Down, Matthew P., Hennig, Matthias, Withers, James P. J. & Hull, Michael.
Publication Date: 2010
Publication Information
Category: Poster
Original Language: English

Projects:
A Phenomenological Approach to Modelling Axon Guidance at the Mouse Optic Chiasm (PhD)